<!DOCTYPE html>
<html lang="en">
<head>
    <meta charset="UTF-8">
    <title>Title</title>
    <style>
        .main {
            width: 500px;
            height: 500px;
            display: grid;
            grid-template-columns:[col1] 1fr [col2] 1fr [col3]  1fr [col4];
            grid-template-rows: [row1] 1fr [row2] 1fr [row3] 1fr [row4];
            background-color: #f9f9f9;
            border: 1px solid red;
        }

        .main div:nth-of-type(1) {
            box-sizing: border-box;
            background-color: pink;
            /*grid-column-start: col1;*/
            /*grid-column-end: col4;*/
            /*grid-row-start: row2;*/
            /*grid-row-end: row3;*/
            /*grid-row: row1 / row3;*/
            /*grid-row: 3 / 4;*/
            /*grid-column: 2 / 4;*/
            /*grid-column-start: span 2;*/
            /*grid-row-start: span 2;*/
            /*grid-column-start: 2;*/
            /*grid-column-end: span 2;*/
            /*grid-row-start: 2;*/
            /*grid-row-end: span 1;*/
            grid-area: 3 / 1 / 4 / 3;
        }
    </style>
</head>
<body>
<div class="main">
    <div>1</div>
</div>
</body>
</html>
